A Pharmacokinetic-Pharmacodynamic Model for Duodenal Levodopa Infusion
نویسندگان
چکیده
منابع مشابه
A pharmacokinetic-pharmacodynamic model for duodenal levodopa infusion.
OBJECTIVE The purpose of this work was to identify and estimate a population pharmacokinetic- pharmacodynamic model for duodenal infusion of a levodopa/carbidopa gel (Duodopa) to examine pharmacological properties of this treatment. METHODS The modeling involved pooling data from 3 studies (on advanced Parkinson disease) and fixing some parameters to values found in literature. The first stud...
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There are many reasons why a clinical neurologist might be concerned about treatment of advanced Parkinson’s disease (PD). Of the current options available, ergot-derived dopamine agonists can cause significant adverse events, such as impulse control disorders1–3 and heart valve abnormalities;4–6 apomorphine infusion is associated with skin reactions;7,8 and deep brain stimulation of the subtha...
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in antimalarial dose optimization 2 3 NJ White 4 5 Mahidol-Oxford Tropical Medicine Research Unit, 6 Faculty of Tropical Medicine, Mahidol University, 7 Bangkok, Thailand. 8 9 Centre for Tropical Medicine, Churchill Hospital, 10 Oxford University, Oxford, United Kingdom 11 12 13 14 15 16 17 Correspondence: 18 Prof NJ White 19 Mahidol-Oxford Research Unit, 20 Faculty of Tropical Medicine, 21 Mah...
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ژورنال
عنوان ژورنال: Clinical Neuropharmacology
سال: 2011
ISSN: 0362-5664
DOI: 10.1097/wnf.0b013e31820b570a